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PRRS Disease Coinfections

PRRS disease coinfections

PRRSv has a wide variety of effects on infected animals and populations depending on the virulence of the PRRSv strain, the age and susceptibility of the animals affected, the environment and management practices (vaccines, biosecurity measures, etc. in which they are living.

Another very important factor when facing a PRRSv infection is the interaction of the virus with other agents present in the farm. Here we review the studied interaction between PRRSv and some of the most frequent pathogens found in our farm.

Is PRRSv frequently detected in combination with other pathogens?

The concurrent presence of PRRSv with one or more viral or bacterial agents was detected already in early outbreaks of the disease. From 1992 to 1994 Zeman (1996) studied 221 different PRRS clinical cases. The author reported concurrent pulmonary infections, predominantly bacterial, in 60.2% of the PRRS pneumonia cases. The 3 most present agents interacting with PRRSv were: P. multocida (30%), S.suis (20%), and H.parasuis (14%). Those concurrent pulmonary infections explain why both interstitial pneumonia and bronchopneumonia lesions are so commonly detected.

Figure1: Percentage of different concurrent agents isolated in PRRS pneumonia


In a more recent study in 147 farms, Velasova (2012) found that 53.3% of PRRSV positive farms were also positive for SIV H1N2 (compared to 40% in PRRS negative farms); this was also observed for SIV H1N (31.1% vs 12.9%), APP (84.8% vs 65.9%). The only exception was PCV2 that was equally found in PRRS positive and negative farms (89.1% vs 89.4%).

In France, Fablet et al (2012) studied and sampled pigs from 125 farms. They found an association between the percentage of pigs with antibodies against PRRSV and the prevalence of M. hyopneumoniae, the percentage of pigs with antibodies against SIV (H1N1 and H1N2) and A. pleuropneumoniae (at 22 weeks).

What is the effect of co-infections of PRRSv and other pathogens?

The previous studies show that there is a clear correlation between the presence of PRRS and the presence of other pathogens in the farms but the effects of the different coinfections are not all the same. In fact, these interactions are not easy to prove and to describe. For this reason several groups have attempted to develop models to study PRRS virus co-infections with various bacteria and viruses.

The following table summarises the results of some of the studies that have been developed in order to explain how does PRRSv interact with different pathogens commonly found in swine farms.

Table 1. Summary of the main interactions found between PRRS and other virus or bacterial swine pathogens

S.suis PRRS enhances susceptibility to S. suis challenge.
A high virulent PRRSV increased more the susceptibility to S. Suis
PRRSV inhibits clearance, which caused higher tissue dissemination and increased S.suis-associated diseases
P. multocida It is one of the most concurrent pathogen in PRRS pneumonia cases (30%) but no interaction has been proven in experimental models.
H. parasuis PRRS infection caused a reduction in H.parasuis phagocytosis
PAMs from PRRSV infected pigs had a lower ability to kill H.parasuis.
App RRSV increased the cases of pneumonia compared to App infection alone
PRRSV predisposes for an aggravation of an App infection
re-infection of PAM’s with APP blocked PRRSv infection
M. hyo Pigs infected with M. hyopneumoniae and PRRSV had more severe clinical disease than the ones infected with only one agent
Animals infected with both agents had a higher percentage of lung lesions, clinical disease, and slower viral elimination than pigs infected with only one agent
SIV Prior PRRSV infection exacerbates the later infection with SIV or PRCV
Co-infection of pigs with PRRSV and SIV created a very severe and lasting respiratory disease
PRCV Prior PRRSV infection exacerbates PRCV-induced clinical illness in co-infected pigs
Suppressed innate NK-cell cytotoxicity occurred in the dual-infected pigs
PCV-2 PRRSV infection resulted in a higher load of PCV2 and in more tissues in PCV2 infected pigs
Microscopic lesions were more severe and found in more tissues in co-infected pigs instead of PCV2 single infected pigs
PRRSV could enhance PCV2 replication while a pre-existing or co-existing PCV2 could partially interfere PRRSV infection


In most of the cases, PRRS acts as an enhancing factor for other concurrent agents, predisposing the pigs to suffer other infections, exacerbating the clinical disease and lesions and prolonging the pneumonia caused by the secondary pathogen. However M.hyo has also been found as a predisposing factor for PRRS infections and in two cases, PRRSv infection were negatively interfered by a previous infection either by APP or PCV-2.

The presence of PRRS together with other concurrent viral and bacteria increases the severity and duration of the respiratory disease. These co-infections, alongside with other factors like environment, management, and animal susceptibility account for a significant share of the differences observed from farm to farm in losses caused by PRRS.

©2017 Boehringer Ingelheim Vetmedica, Inc.